The dry eye treatment changing ocular surface management for Ophthalmologists across the US.
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Introducing LACRIFILL® Canalicular Gel
Ophthalmologists, meet LACRIFILL® Canalicular Gel, the essential new addition to your clinical practice.
Are your patients struggling with dry eye after surgery and not finding daily eye drops helpful? Are punctal plugs not providing the relief they need, and are they returning with complaints about discomfort, dislodging, even infection?
LACRIFILL® Canalicular Gel is a new intervention that can help you treat dry eye before and after cataract, glaucoma and other refractive surgeries. It also can help patients with dry eye symptoms, whatever the cause, that aren›t relieved by other therapies. This proprietary, novel cross-linked Hyaluronic Acid gel is used to fill the lacrimal caniculi so that patient’s eyes are bathed in their own natural tears.
75% of patients had dry eye prior to cataract surgery
Trattler WB, Majmudar PA, Donnenfeld ED, McDonald MB, Stonecipher KG, Goldberg DF, The Prospective Health Assessment of Cataract Patients’ Ocular Surface (PHACO) study: the effect of dry eye, Clinical Ophthalmology, 7 August 2017
37.4% of patients without dry eye developed dry eye after cataract surgery
Miura Prevalence and Characteristics of Dry Eye Disease After Cataract Surgery- A Systematic Review and Meta-Analysis. Ophthalmol Ther, 2022
28% had symptoms of dry eye at 3 months after LASIK
Eydelman Symptoms and Satisfaction of Patients in the Patient-Reported Outcomes With Laser In Situ Keratomileusis (PROWL) Studies JAMA Oph, 2016
Clinically Proven
LACRIFILL® Canalicular Gel has been cleared for use by the FDA based on the results of clinical studies showing it’s safe for patients and effective at keeping natural tears in the eye.
Proof-of-Concept Study
A pilot study of LACRIFILL® Canalicular Gel involving 63 patients with dry eye found there was an increase in tears remaining on the eye and an increase in tear volume, lasting for at least 3 months.
83% of patients had no pain
94% of patients had no infections
63% reported their eyes felt better
Fezza JP, Cross-linked hyaluronic acid occlusive device for the treatment of dry eye syndrome, Clinical Ophthalmology 2018_12: 2777-2283
Clinical Trial Results
The findings below were published in the October 2024 issue of the Journal of Cataract and Refractive Surgery (JCRS) in the “Effectiveness and safety of a novel crosslinked hyaluronate canalicular gel occlusive device for dry eye” article.
Based on the Pivotal Study
Change from Baseline of Anesthetized Schirmer’s Test (Averages of Both Eyes) at all Post-Baseline Visits
ITT Population with Available Data Only
Average of Both Eyes
Anesthetized Schirmer’s Test
Change from Baseline of Corneal Fluorescein Staining
(NEI Scale; Averages of Both Eyes) at all Post-Baseline Visits
ITT Population with Available Data Only
Average of Both Eyes
Fluorescein Staining NEI Scale – Central
Planned Treatment: Oasis Form Fit Hydrogel Canalicular Plug Lacrifill Canalicular Plug
Packer M, Lindstrom R, Thompson V, Parekh JG, Gupta P, Nijm LM, Donnenfeld E. Effectiveness and safety of a novel crosslinked hyaluronate canalicular gel occlusive device for dry eye. J Cataract Refract Surg. 2024 Oct 1;50(10):1051-1057.
doi: 10.1097/j.jcrs.0000000000001505. PMID: 38875184
For a full listing of Adverse Events associated with LACRIFILL
Patient Satisfaction Data
98% of first time users of LACRIFILL® Canalicular Gel reported they will come back for a future dose of LACRIFILL.
Read the published Patient Data online on the Cataract & Refractive Surgery Today website here.
Integrate Confidently: How to Administer LACRIFILL & On-Demand Educational Content
- LACRIFILL comes in a pre-filled injector with enough gel to treat the lower and upper canaliculi.
- A cannula tip** is placed in the punctum and the LACRIFILL gel is inserted.
- The gel flows through the punctum into the lacrimal sac.
- If you see the gel extruding from the upper punctum, you know that both the upper and lower puncta have been blocked.**Clinical discretion can be used for the appropriate cannula size.
Full Instructions for Use
How to Administer LACRIFILL®
Additional, On-Demand Education Content is available on the LACRIFILL Website. Please visit our Resources Center.
